How To Prevent Peyronie's Disease

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How To Prevent Peyronie's Disease

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Although there is no panacea for the treatment of Peyronie’s disease, the best results have been reported when using a combination of treatment options, including a healthy lifestyle and focused shock waves (Kuhs et al., 2011). Focused shock waves (the focus of this article) are a safe and effective method used to destroy the plaque associated with Peyronie’s disease and stimulate the healing process.

This article explains how Peyronie’s disease occurs, answers frequently asked questions, and discusses the best treatment options based on available research, including focused shock waves.

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Peyronie’s disease is defined as “an acquired change in the shape of the penis during erection” (Gholami, 2012). Penile deformities associated with Peyronie’s disease typically occur after a traumatic event and include one or more of the following features:

The penile shaft contains the corpus cavernosum (two long columns of smooth muscle that contract to produce an erection) and the urethra (for urination). This structure is surrounded by the tunica albuginea. The tunica albuginea is a thick fibrous tissue that covers the internal structures of the penis and protects it from injury.

When the penis is exposed to trauma, it may bleed and become trapped within the tunica albuginea. In some cases, an inadequate healing process may occur, resulting in the formation of scar tissue plaques in the penile shaft, leading to Peyronie’s disease (Ferrell et al., 2020; Gholami et al., 2003).

Peyronie’s Disease: Types, Symptoms, Causes, Diagnosis, Treatment And More

Conversely, the formation of plaques on the shaft of the penis can also occur naturally with age or normal sexual activity. Many of these have no symptoms and resolve spontaneously over time (Gholami, 2012).

In the early stages, plaques begin to form on the body of the penis and deformity begins. The initial stages are often accompanied by painful erections.

In the final stage, the plaque hardens and stabilizes, as does a change in the shape of the penis. Often, the pain associated with Peyronie’s disease resolves, leaving only the deformity.

Peyronie’s disease is a relatively common condition that affects up to 10% of men at some point in their lives. Although the incidence increases with age and the average age of onset is 53 years, it can occur in men of any age (Ferrell et al., 2020; Gholami et al., 2003). Peyronie disease is also associated with other soft tissue diseases such as Dupuytren’s contracture of the hand, plantar fascia contracture, diabetes, gout, regular use of beta-blockers, and Paget’s disease (Gholami et al., 2003).

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A diagnosis of Peyronie’s disease is made by a doctor or urologist and involves an in-depth medical interview (often involving sexual partners) and a series of nuanced questions about:

After the interview, the penis should be evaluated. The doctor feels the body of the penis to check for plaque formation, soft tissue thickening, and deformities.

Ultrasound imaging is particularly useful for assessing the exact location of plaque formation as well as any vascular changes that may be present using an ultrasound technique known as penile duplex Doppler (Gholami et al., 2022; Zigelman et al., 2020).

Achieving the correct diagnosis (early or late stage) and understanding comorbidities help select the right treatment plan (Ziegelmann et al., 2020).

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Focused shock waves use a process called mechanical transmission. Mechanotransduction converts mechanical stimulation (generated by a focused shock wave device) into a cellular response (in vivo) that stimulates plaque breakdown and restarts the healing process of damaged target tissues.

The concentrated shock wave creates a series of high-pressure shock waves. Each shock wave is very short and is quickly followed by another. Sound waves are known as pulses. Each pulse triggers a phenomenon called acoustic cavitation. Acoustic cavitation creates a series of bubbles in the target tissue, allowing the previously mentioned biological processes to occur (Abdessater et al., 2022).

Focused shock waves have been approved for the treatment of Peyronie’s disease by the National Institute for Health and Care Excellence (NICE, 2017) and have been shown to be a safe and non-invasive method of treating patients with Peyronie’s disease (Di Mauro et al., 2019). ). This is particularly effective in patients who have not responded to other conservative treatment options (Shimpi and Jain, 2016).

Studies have shown that focused shock waves significantly improve pain associated with Peyronie’s disease and also reduce plaque formation on the penile shaft. However, it did not appear to have a significant effect on penile deformities (Abdessater et al., 2022; Ziegelmann et al., 2020).

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A focused shock wave therapy session delivers up to 4,000 pulses and takes approximately 5 minutes to complete. A full course of focused shock wave therapy for Peyronie’s disease consists of six treatments spaced 1 week apart (Abdessater et al., 2022).

Oral and topical (cream) nonsteroidal anti-inflammatory drugs may be useful in the management of pain associated with Peyronie’s disease (Abdessater et al., 2022; Ziegelmann et al., 2020).

Stretching for the treatment of Peyronie’s disease has been shown to be very effective in correcting curve deformity, with a 75% success rate. Stretching can be used in conjunction with other treatments and should be offered to all patients with Peyronie’s disease (Ziegelmann et al., 2020).

Verapamil, commonly used to lower blood pressure, has also been shown to interfere with the improper healing process associated with plaque formation in patients with Peyronie’s disease (Randhawa and Shukla, 2019).

What Are The Types Of Treatments For Peyronie’s Disease?

Verapamil injection directly targets plaque formation.

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